Kent L. Hill, Ph.D.

Langousis Gerasimos, Shimogawa Michelle M, Saada Edwin A, Vashisht Ajay A, Spreafico Roberto, Nager Andrew R, Barshop William D, Nachury Maxence V, Wohlschlegel James A, Hill Kent L   Loss of the BBSome perturbs endocytic trafficking and disrupts virulence of Trypanosoma brucei Proceedings of the National Academy of Sciences of the United States of America, 2016; 113(3): 632-7.

Saada Edwin A, DeMarco Stephanie F, Shimogawa Michelle M, Hill Kent L   “With a Little Help from My Friends”-Social Motility in Trypanosoma brucei PLoS pathogens, 2015; 11(12): e1005272.

Shimogawa Michelle M, Saada Edwin A, Vashisht Ajay A, Barshop William D, Wohlschlegel James A, Hill Kent L   Cell Surface Proteomics Provides Insight into Stage-Specific Remodeling of the Host-Parasite Interface in Trypanosoma brucei Molecular & cellular proteomics : MCP, 2015; 14(7): 1977-88.

Oberholzer Michael, Saada Edwin A, Hill Kent L   Cyclic AMP Regulates Social Behavior in African Trypanosomes mBio, 2015; 6(3): e01954-14.

Lopez Miguel A, Saada Edwin A, Hill Kent L   Insect stage-specific adenylate cyclases regulate social motility in African trypanosomes Eukaryotic cell, 2015; 14(1): 104-12.

Saada Edwin A, Kabututu Z Pius, Lopez Miguel, Shimogawa Michelle M, Langousis Gerasimos, Oberholzer Michael, Riestra Angelica, Jonsson Zophonias O, Wohlschlegel James A, Hill Kent L   Insect stage-specific receptor adenylate cyclases are localized to distinct subdomains of the Trypanosoma brucei Flagellar membrane Eukaryotic cell, 2014; 13(8): 1064-76.

Freire Eden R, Vashisht Ajay A, Malvezzi Amaranta M, Zuberek Joanna, Langousis Gerasimos, Saada Edwin A, Nascimento Janaína De F, Stepinski Janusz, Darzynkiewicz Edward, Hill Kent, De Melo Neto Osvaldo P, Wohlschlegel James A, Sturm Nancy R, Campbell David A   eIF4F-like complexes formed by cap-binding homolog TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma brucei RNA (New York, N.Y.), 2014; 20(8): 1272-86.

Langousis Gerasimos, Hill Kent L   Motility and more: the flagellum of Trypanosoma brucei Nature reviews. Microbiology, 2014; 12(7): 505-18.

Freire Eden R, Malvezzi Amaranta M, Vashisht Ajay A, Zuberek Joanna, Saada Edwin A, Langousis Gerasimos, Nascimento Janaína D F, Moura Danielle, Darzynkiewicz Edward, Hill Kent, de Melo Neto Osvaldo P, Wohlschlegel James A, Sturm Nancy R, Campbell David A   Trypanosoma brucei translation initiation factor homolog EIF4E6 forms a tripartite cytosolic complex with EIF4G5 and a capping enzyme homolog Eukaryotic cell, 2014; 13(7): 896-908.

Kisalu Neville K, Langousis Gerasimos, Bentolila Laurent A, Ralston Katherine S, Hill Kent L   Mouse infection and pathogenesis by Trypanosoma brucei motility mutants Cellular microbiology, 2014; 16(6): 912-24.

Nguyen Hoangkim T, Sandhu Jaspreet, Langousis Gerasimos, Hill Kent L   CMF22 Is a Broadly Conserved Axonemal Protein and Is Required for Propulsive Motility in Trypanosoma brucei Eukaryotic cell, 2013; 12(9): 1202-13.

Louise C. Hughes, Katherine S. Ralston, Kent L. Hill1, Z. Hong Zhou   Three-Dimensional Structure of the Trypanosome Flagellum Suggests that the Paraflagellar Rod Functions as a Biomechanical Spring, PLoS One, 2012; 7(1):e25700. Epub 2012 Jan 3.(1): e25700.
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Hughes Louise C, Ralston Katherine S, Hill Kent L, Zhou Z Hong   Three-dimensional structure of the Trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical spring PloS one, 2012; 7(1): e25700.

Lopez Miguel A, Nguyen HoangKim T, Oberholzer Michael, Hill Kent L   Social parasites Current opinion in microbiology, 2011; 14(6): 642-8.

Oberholzer Michael, Langousis Gerasimos, Nguyen HoangKim T, Saada Edwin A, Shimogawa Michelle M, Jonsson Zophonias O, Nguyen Steven M, Wohlschlegel James A, Hill Kent L   Independent analysis of the flagellum surface and matrix proteomes provides insight into flagellum signaling in mammalian-infectious Trypanosoma brucei Molecular & cellular proteomics : MCP, 2011; 10(10): M111.010538.

Ralston Katherine S, Kisalu Neville K, Hill Kent L   Structure-function analysis of dynein light chain 1 identifies viable motility mutants in bloodstream-form Trypanosoma brucei Eukaryotic cell, 2011; 10(7): 884-94.

Merveille et al.   CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs. Nature Genetics, 2011; 43: 72-78.

Oberholzer,M., Langousis,G., Nguyen,H., Saada, E., Shimogawa, M., Jonsson, Z., Nguyen, S., Wohlschlegel, J.A. and Hill, K.L.   Independent analysis of the flagellum surface and matrix proteomes provides insight into flagellum signaling in mammalian-infectious Trypanosoma brucei, Mol. & Cell. Proteomics, 2011; Oct;10(10):M111.010538. Epub 2011 Jun 19.: .

Lopez, M.A. Nguyen, H.T. Oberholzer, M. Hill, K.L.   Social Parasites, Curr. Opin. Microbiol, 2011; In Press: .

Ralston, K.R. Kisalu, N.K. Hill, K.L.   Structure-function analysis of dynein light chain 1 identifies viable motility mutants in bloodstream-form Trypanosoma brucei , Euk Cell, 2011; In Press: .

Kabututu Zakayi P, Thayer Michelle, Melehani Jason H, Hill Kent L   CMF70 is a subunit of the dynein regulatory complex Journal of cell science, 2010; 123(Pt 20): 3587-95.

Hill Kent L   Parasites in motion: flagellum-driven cell motility in African trypanosomes Current opinion in microbiology, 2010; 13(4): 459-65.

Kabututu, P.K. Thayer, M. Melehani, J.H. Hill, K.L.   CMF70 is a subunit of the dynein regulatory complex, J. Cell Science, 2010; 123: 3587-95.

Oberholzer, M., Lopez, M., McLelland, B., Hill, K.L.   Social motility in African trypanosomes, PLoS Pathogens, 2010; Jan 29;6(1):e1000739: .

Oberholzer Michael, Lopez Miguel A, McLelland Bryce T, Hill Kent L   Social motility in african trypanosomes PLoS pathogens, 2010; 6(1): e1000739.

Oberholzer, M. Lopez, MA, Ralston, KS, Hill, KL   Approaches for functional analysis of flagellar proteins in African trypanosomes, Methods in Cell Biology, 2009; 93: 21-57.

Rodríguez,JA, Lopez, MA, Thayer, MC, Zhao, Y, Oberholzer, M, Chang, D, Kisalu, NK, Penichet, ML, Helguera, G, Bruinsma, R, Hill, KL and Miao, J   Propulsion of African trypanosomes is driven by bihelical waves with alternating chirality separated by kinks, Proc. Natl. Acad. Sci, 2009; 106(46): 19322-19327.

Ralston, K.S., Kabututu, Z.P., Melehani, J.H., Oberholzer, M. Hill, K.L.   The Trypanosoma brucei flagellum: moving parasites in new directions, Annual Review of Microbiology, 2009; 63: 335-62.

Colantonio, JR, Vermot, J., Wu, D. Langenbacher, A., Fraser, S. Chen, JN and Hill, K.L.   The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear Nature, 2009; 457: 205-209.

Oberholzer Michael, Lopez Miguel A, Ralston Katherine S, Hill Kent L   Approaches for functional analysis of flagellar proteins in African trypanosomes Methods in cell biology, 2009; 93(7226): 21-57.

Ralston Katherine S, Kabututu Zakayi P, Melehani Jason H, Oberholzer Michael, Hill Kent L   The Trypanosoma brucei flagellum: moving parasites in new directions Annual review of microbiology, 2009; 63(7226): 335-62.

Colantonio Jessica R, Vermot Julien, Wu David, Langenbacher Adam D, Fraser Scott, Chen Jau-Nian, Hill Kent L   The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear Nature, 2009; 457(7226): 205-9.

Ralston Katherine S, Hill Kent L   The flagellum of Trypanosoma brucei: new tricks from an old dog International journal for parasitology, 2008; 38(8-9): 869-84.

Ralston, K.S. and Hill, K.L.   The flagellum of Trypanosoma brucei: new tricks from an old dog Intl. J. Parasitol, 2008; 38: 869-864.
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Bekker, J.M., J.R. Colantonio, A.D. Stephens, W.T. Clarke, S.J. King, K.L. Hill, and R.H. Crosbie.   Direct Interaction of Gas11 with Microtubules: Implications for the Dynein Regulatory Complex. Cell Motility and the Cytoskeleton Cell Motility and the Cytoskeleton, 2007; 64: 461-473.

Baron, D. M., Ralston, K. S., Kabututu, Z. P. and Hill, K. L.   Functional Genomics in Trypanosoma brucei Identifies Evolutionarily-Conserved Components of Motile Flagella J. Cell Science, 2007; 120: 478-491.

Baron, D. M. Kabututu, Z. P. Hill, K. L   Stuck in reverse: loss of the dynein light chain LC1 disrupts outer dynein arms, and leads to reverse flagellar beat and backward cell movement in Trypanosoma brucei J. Cell Science, 2007; 120: 1513-1520.
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Bekker Janine M, Colantonio Jessica R, Stephens Andrew D, Clarke W Thomas, King Stephen J, Hill Kent L, Crosbie Rachelle H   Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex Cell motility and the cytoskeleton, 2007; 64(6): 461-73.

Baron Desiree M, Kabututu Zakayi P, Hill Kent L   Stuck in reverse: loss of LC1 in Trypanosoma brucei disrupts outer dynein arms and leads to reverse flagellar beat and backward movement Journal of cell science, 2007; 120(Pt 9): 1513-20.

Baron Desiree M, Ralston Katherine S, Kabututu Zakayi P, Hill Kent L   Functional genomics in Trypanosoma brucei identifies evolutionarily conserved components of motile flagella Journal of cell science, 2007; 120(Pt 3): 478-91.

Colantonio JR, Bekker JM, Kim SJ, Morrissey KM, Crosbie RH and Hill KL   Expanding the Role of the Dynein Regulatory Complex to Non-Axonemal Functions: Traffic, 2006; 7(5): 538-548.
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Ralston KS, Lerner AL, Deiner DR and Hill KL   Flagellar motility contributes to cytokinesis in Trypanosoma brucei and is modulated by an evolutionarily-conserved dynein regulatory system. Euk. Cell, 2006; 5, 696-711: .
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Ralston, K.S., and K.L. Hill.   Trypanin, a comonent of a flagellar dynein regulatory complex, is essential in bloodstream-form Trypanosoma brucei. PLoS Pathogens, 2006; 2(9): 873-882.
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Hill KL   Biology and mechanism of trypanosome cell motility Euk. Cell. , 2003; 2(2): 200-8.

Yi CE, Bekker JM, Miller G, Hill KL, Crosbie RH   Specific and potent RNA interference in terminally differentiated myotubes J. Biol. Chem. , 2003; 278(2): 934-9.

Hutchings NR, Donelson JE, Hill KL   Trypanin is a cytoskeletal linker protein and is required for cell motility in African trypanosomes J. Cell Biol. , 2002; 156(5): 867-77.
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Hill KL, Hutchings NR, Grandgenett PM, Donelson JE   T lymphocyte-triggering factor of african trypanosomes is associated with the flagellar fraction of the cytoskeleton and represents a new family of proteins that are present in several divergent eukaryotes J. Biol. Chem, 2000; 275(50): 39369-78.

LaCount DJ, Bruse S, Hill KL and Donelson JE   Double-stranded RNA interference in Trypanosoma brucei, Mol. Biochem. Parasitol, 2000; 111: 67-76.

Hill KL, Hutchings NR, Russell DG and Donelson JE   A novel protein targeting domain confers flagellar pocket targeting in African trypanosomes J. Cell Science, 1999; 112: 3091-3101.

Hill KL and Donelson JE   Antigenic variation in microbial pathogens, The Encyclopedia of Genetics, 1999; .

Hill KL and Coughlin BC   Gene rearrangement in eukaryotic organisms, The Encyclopedia of Genetics, 1999; .

Teixeira SM, Otsu K, Hill KL, Kirchhoff LV, Donelson JE   Expression of a marker for intracellular Trypanosoma cruzi amastigotes in extracellular spheromastigotes Mol. Biochem. Parasitol, 1999; 98(2): 265-70.

Donelson JE, Hill KL, El-Sayed NM   Multiple mechanisms of immune evasion by African trypanosomes Mol. Biochem. Parasitol, 1998; 91(1): 51-66.

Vaidya T, Bakhiet M, Hill KL, Olsson T, Kristensson K, Donelson JE   The gene for a T lymphocyte triggering factor from African trypanosomes J. Exp. Med , 1997; 186(3): 433-8.

Hill KL, Catlett NL, Weisman LS   Actin and myosin function in directed vacuole movement during cell division in Saccharomyces cerevisiae J. Cell Biol, 1996; 135(6 Pt 1): 1535-49.